clodrosome macrophage depletion kit

and sacrificed at 14 days P.I. Standard macrophage depletion kit- The kit is composed of one 2 ml vial of Clodrosome (Clodronate liposomes) and one 2 ml vial of Encapsome (plain liposomes for control). PD-L1 expres- To deplete macrophages, 2.5 ml clodrosome (Liposomal Clodronate, 5 mg/ml, Clodrosome Macrophage Depletion kit, Encapsula Nano Science) were injected into a rat through the tail vein. m-Clodrosome® and m-Encapsome® are mannosylated reagents that are specifically formulated to efficiently target the macrophages in central nervous systems and . macrophages in vivo. For the CD1 wild-type, the animals were injected 200 μl of either solution intraperitoneally. Contain unmodified multilamellar liposomes similar to those used in most published depletion studies. Select quantity or request quotation for larger quantities. need details on ordering and payment, see the Ordering Info page. Encapsula Nano S ciences Product Information Version: 02/15/12 Clodrosome® Macrophage Depletion Kit Refrigerate at 4°C - DO NOT FREEZE Kit Contents: 1. 3 - 5 June 2021, The University of Foggia, Italy. Standard macrophage depletion kit (composed of one vial of Clodrosome® and one vial of Encapsome®) Mice were injected IP with 80µl containing 0.4mg clodronate or control liposomes (Clodrosome macrophage depletion kit, Encapsula Nano Sciences; Brentwood, TN; No. . mice i.t. ; 200 μl; 5 mg/ml) three times at seven days apart during the RS paradigm . Article Snippet: Phagocyte depletion using clodronate liposomes Naïve female mosquitoes (4- to 6-day old) were injected intra-thoracically with either 69 nl of control liposomes (LP) or clodronate liposomes (CLD) (Standard macrophage depletion kit, Encapsula NanoSciences LLC) using a Nanoject II injector (Drummond Scientific). Depletion of tumor-associated macrophages decreases the growth of tumors in the transplantable tumor model. 24,25 Clodrosome was suspended in phosphate-buffered saline (PBS), 1 mL of suspension contained 5 mg clodronate, 18.8 mg phosphatidylcholine, and 4.2 mg cholesterol. the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how . $396.80 / Each; Qty Add to cart . Liposome size range (0.3-3 µm) is optimal for immediate phagocyte recognition and uptake. When tumors became palpable, subcutaneous injection of 200 µL (5 mg/mL) of Clodrosome (clodronate-encapsulated liposomes), or vehicle Encapsome (PBS liposomes), was administered twice per . Mice were maintained under specific-pathogen-free conditions in the vivarium of Emory Vaccine Center. For macrophage depletion, OS17 solid tumor-bearing nude mice were injected with liposomal clodronate (Clodrosome; Encapsula NanoSciences LLC, Brentwood, TN, USA) intraperitoneally 6 days prior to MSC injection and then every 3 days to maintain depletion. Large selection of macrophage/monocyte depletion kits and reagents. Home; About the conference. Dec 16th. Naïve tumors showed significantly more positive area of F4/80 using IHC . Keynote-Speakers; Board. Macrophage depletion. The median survival time of transplanted islets (Islet-Matrigel-Clodrosome group) was significantly increased (>60 days), compared to other groups. To order using a credit card, select a volume of the desired product and click "add to cart". Role of Copper Efflux in Pneumococcal Pathogenesis and Resistance to Macrophage-Mediated Immune Clearance. We used the Clodrosome® Fluorescent-DiI Macrophage Depletion Kit (Encapsula Nano Sciences, Brentwood, TN), which includes a suspension of 1.5-2 μm liposomes consisting of non-toxic L-alpha-phosphatidylcholine and cholesterol, labeled with 1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindocarbocyanine (DiI) and containing either disodium . Macrophages are present in nearly every tissue of the body and are important for maintaining homeostasis, but their dysfunction can also lead to diseases, such as inflammatory bowel disease. Cell depletion confirmed by flow cytometric analysis of splenocytes for NK (CD49d+) or . PD-L1 expression was observed in human OS cells and OS patient lung metastases. Encapsula NanoSciences is a specialty company focused on providing liposome research, development and manufacturing expertise in the production of lipid-based nanoparticles, also known as liposomes, to clients and partners in both the academic and industrial sectors. Clodrosome Depletion of Macrophages Enhances OV Efficacy (A) Treatment regimen of A673 tumor xenograft-bearing mice given 400 μg of liposome or Clodrosome intravenously (i.v.) For macrophage depletion, Clodrosome or Encapsome was used from the standard macrophage depletion kit (Encapsula NanoSciences, Brentwood, TN) as suggested. Hematogenous macrophages were depleted with clodronate liposomes. At 24 h after clodrosome treatment, AMin BALF signifi-cantly decreased from ∼30 to ∼2% (Fig. 8901) Trypsin/EDTA solution (Life Technologies, cat. treatments. Forty hours after clodrosome or encapsome injection, the rats were injected ip . Standard macrophage depletion kit . To study the role macrophages play in a complex in vivo environment, depletion and reconstitution experiments can be utilized. For macrophage depletion, Clodrosome or Encapsome was used from the standard macrophage depletion kit (Encapsula NanoSciences, Brentwood, TN) as suggested. the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how . Hi, did anyone use the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how to prepare it before injection? The clodronate-containing liposomes will be recognized as foreign particles and get . To deplete macrophages, 2.5ml clodrosome (Liposomal Clodronate, 5 mg/ml, Clodrosome Macrophage Depletion kit, Encapsula Nano Science) were injected into a rat through the The information in the Announcement section below the server status section may give you an idea about when to expect the issues to be resolved. The mice were anesthetized by inhalation of 4% isoflurane (Piramal), then each mouse in the . NC1643785. Control rats were injected with the same amount of encapsome (control liposomes). Micron sized liposomes engineered specifically to target macrophages in different tissues and organs. Intraperitoneal administration of 200 μl of Encapsome or clodronate liposomes (5 mg/ml) was performed three times at 7 days apart . To deplete macrophages, 2.5 ml clodrosome (Liposomal Clodronate, 5 mg/ml, Clodrosome Macrophage Depletion kit, Encapsula Nano Science) were injected into a rat through the tail vein. The depletion of T cells and macrophages were conducted as previously described.30 Mice-bearing 4T1 tumor were intraperitoneally injected twice before the initial treatment at a 72 hours interval with anti-CD8 antibodies (400 µg, BioXCell, West Lebanon, USA, clone 2.43), anti-CD4 antibodies (400 µg, BioXCell, clone GK1.5), or clodrosome (50 . Clodrosome Macrophage Depletion Kits and Reagents. The mannosylated-Clodrosome Macrophage Depletion Kit (m-Clodrosome: 5 mg/ml Clodronate Disodium Salt, 18.8 mg/ml L-α-Phosphatidylcholine, 4.2 mg/ml Cholesterol, and 1 mg/ml 4-Aminophenyl-alpha-D-Mannopyranoside; Encapsula NanoSciences, Brentwood, TN, United States) was used to deplete M2 macrophages from the PSL mice. The doses of injected clodronate were 25 and 12.5 μg per g body weight per day for day 0 and day 1, respectively. A Clodrosome Macrophage Depletion Kit, containing control liposomes (Encapsome) and clodronate liposomes (Clodrosome) (Encapsula NanoSciences, Brentwood, TN), was used to deplete endogenous monocytes/macrophages. 7 A). Clodronate-liposome treatment is widely used for macrophage depletion, . Clodrosome is a Liposomal Clodronate, and . A clodronate macrophage depletion kit, containing control liposomes (Encapsome) and clodronate liposomes (Clodrosome; Encapsala NanoSciences), was used to deplete endogenous myeloid cells. Control rats were injected with the same amount of encapsome (control liposomes). Clodrosome® is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. Clodronate has previously been used to deplete the number of macrophages in the lungs. Control mice were given the same amount of control liposome suspension. Lipid Nanoparticles. A clodronate macrophage depletion kit, containing control liposomes (encapsome) and clodronate liposomes (clodrosome) (Encapsala NanoSciences, Brentwoood, TN), was utilized to deplete endogenous myeloid cells. on days −2, −1, and 0 followed by weekly i.p. Encapsome® is formulated and prepared identically to Clodrosome® except that clodronate is not added to the liposomes. Mannosylated Clodrosome Macrophage Depletion Kits. Large selection of macrophage/monocyte depletion kits and reagents. Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. 10010049) CD1 wild-type and TCF/Lef:H2B-GFP reporter mice mice were injected with a macrophage depletion kit Clodrosome and Encapsome (Encapsula NanoSciences). Locally co-delivered pancreatic islets and liposomal clodronate using injectable hydrogel effectively cured type 1 diabetes. Macrophage depletion kit is composed of one vial of Clodrosome® and one vial of Encapsome®. As an example, a 5-ml kit is composed of 5 ml Clodrosome® and 5 ml Encapsome®. The effect of tumor macrophages on oncolytic virus therapy, however, is variable among solid tumors and is unknown in Ewing sarcoma. Standard Macrophage Depletion Kit (Clodrosome + Encapsome) was purchased from Encapsula Nanosciences (CLD-8901). Mice, with or without AMdepletion, were subjected to HS and resuscitation, and at 8 h afterresuscitation,alveolarPMNsweredefinedasLy6G-positivecells by flow cytometry, and cell death was assessed by double-positive Macrophage depletion in mice Macrophage depletion in vivo used Clodrosome, WT-RDNV/CLD, KO-RDNV/CLD, and the PBS control with equal amounts of clodronate. no. no. Cytotoxicity of Bisphosphonates such as Clodronate, Pamidronate and Zelodronate. Menu. Macrophages infiltrating the colon cancers in this model secrete the inflammatory mediators CCL2, IL-1a, IL-6 and TNFa. These kits are also available with various fluorescent control reagents such as DiI (ex/em: 549/565 nm), DiO (ex/em:484/501 nm), DiD (ex/em: 644/665 nm), DiA (ex/em: 456/590 . Macrophage Depletion. The liposomes are filtered through 2 μm polycarbonate membranes to ensure that the larger particles, which may be toxic to animals, are . on day −3 and intraperitoneally (i.p.) Click on "More Info" for product details, or if you. treatments. Michael D. L. Johnson, a. Thomas E. Kehl-Fie, ENCAPSULA NANAOSCIENCE LLC MACROPHAGE DEPLETION KIT 2ML . Could you kindly provide . no. Liposomal clodronate suspension (500 mg/mouse) was administered intratracheally in a volume of 100 ml 3 h after the coad-ministration of IL-33 and IL-17A. administered one day before the third and fourth dose of +--++--+. 4-Aminophenyl-alpha-D- Mannopyranoside incorporated into the liposomes. NK cell and macrophage depletion were conducted using anti-asialo GM1 and clodrosome, respectively. Large selection of macrophage/monocyte depletion kits and reagents. Intraperitoneal administration of 200 µl of placebo or clodronate liposomes (5 mg/ml) was performed once daily for three consecutive days. Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Contact Encapsula NanoSciences LLC 5409 Maryland Way Suite 360 Brentwood, TN 37027 Phone: 615-884-4442 Fax: 615-250-8747 URL: www.encapsula.com . The depletion of T cells and macrophages were conducted as previously described.30 Mice-bearing 4T1 tumor were intraperitoneally injected twice before the initial treatment at a 72 hours interval with anti-CD8 antibodies (400 µg, BioXCell, West Lebanon, USA, clone 2.43), anti-CD4 antibodies (400 µg, BioXCell, clone GK1.5), or clodrosome (50 . Tuber analysis was used to further determine angiogenetic effect . Adoptive transfer. Standard macrophage depletion kit (Clodrosome, cat. Several strategies were taken to verify the contribution of M2 macrophage and CHI3L1: macrophage depletion by clodrosome, local CHI3L1 inhibition using intravitreally injection neutralize antibody (mAY), and depletion of CHI3L1 receptor (IL13-Ra2) by small-interfering RNA (siRNA). For macrophage depletion, mice were intrathecally injected on day 4 after the first dose of cisplatin under isoflurane anesthesia with 10 μL of either empty liposomes or clodronate-containing liposomes from the mannosylated macrophage depletion kit (catalog CLD-8914, Encapsula Nano Sciences) . Encapsome or clodronate liposomes were administered (i.p. Depletion of alveolar macrophages reduces mouse cytomegalovirus (MCMV)-3DR infection in the neonatal lung. Catalog No. on day −3 and intraperitoneally (i.p.) Standard macrophage depletion kit (composed of one vial of Clodrosome® and one vial of Encapsome®) How does Clodrosome® (Clodronate encapsulated liposome) kill macrophages? Mannosylated macrophage depletion kit is composed of one vial of m-Clodrosome® and one vial of m-Encapsome®. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma. 8901) every 3 days from 6 to 12 days P.I. a Representative images of tissue sections immunostained for macrophages (F4/80), B cells (B220) or T cells (CD3, CD8, Foxp3) in gastric tumor sections of gp130 FF; c-Kit +/+ and mast cell . Mice with Lkb1-deficient AMs exhibited deteriorated diseases during airway Staphylococcus aureus (S. aureus . Large selection of macrophage/monocyte depletion kits and reagents. In order to deplete LN-resident macrophages, 0.25 mg (50 μl) of Clodrosome (CLL) and Encapsome (control liposome) were subcutaneously injected 5 days prior to each vaccination. on days −2, −1, and 0 followed by weekly i.p. We next examined how M2 macrophage depletion by m-Clodrosome affects the MCP-1/sSiglec-9-mediated FN regeneration. Dec 16th. Hi, did anyone use the Clodrosome® standard macrophage depletion kit (containing Clodronate liposome and control liposomes), and know how to prepare it before injection? Clodronate liposomes or empty liposomes were injected into mice 36 h before tMCAO (i.p., 75 mg/kg). BASIQ 2021. Five animals received clodronate liposomes and five animals received control liposomes. CD1 wild-type and TCF/Lef:H2B-GFP reporter mice mice were injected with a macrophage depletion kit Clodrosome and Encapsome (Encapsula NanoSciences). ( a - j ) Phosphate-buffered saline (PBS), encapsome, or clodrosome was . NK cell and macrophage depletion were conducted using anti-asialo GM1 and clodrosome, respectively. Especially, the inhibition of macrophage attack in the early stage after local delivery of islets was very important for the successful long-term survival of delivered islets. Could you kindly provide . Apr 23rd. NC0302518 $272.80 / Each Encapsula has no control over the Caspio Server Status, however if you experience excessive access issues, please email us at [email protected] with the details. NK and macrophages were assessed using flow cytometry. Clodrosome is a Liposomal Clodronate, and Encapsome is the Control Liposomes. The subcellular fractionation study indicates that mannose labeled liposomes are incorporated into lysosomes rich fraction both in liver and brain. Clodronate-liposome treatment is widely used for macrophage depletion, . Clodrosome Depletion of Macrophages Enhances OV Efficacy (A) Treatment regimen of A673 tumor xenograft-bearing mice given 400 μg of liposome or Clodrosome intravenously (i.v.) 1A). R001100) PBS (Life Technologies, cat. Treatment with m-Clodrosome, but not the control liposome (Encapsome), prevented the MCP-1/sSiglec-9-mediated conversion of the FNI-induced pro-inflammatory environment to an anti-inflammatory one (Fig. Manufacturer: ENCAPSULA NANAOSCIENCE LLC CLD89142ML Mannosylated Macrophage Depletion Kit (m-Clodrosome® + m-Encapsome®) 2ml. As an example, a 5-ml kit is composed of 5 ml m-Clodrosome® and 5 ml m-Encapsome®. Clodrosome巨噬细胞消耗试剂盒包含与大多数已发表的枯竭研究中使用的类似的未修饰的多层脂质体脂质体大小范围（0.3-3 m）对于立即吞噬细胞的识别和摄取是zui佳的试剂盒包含相同体积的 . Locally delivered liposomal clodronate in matrigel effectively inhibited the activation of macrophages, immune cell migration and activation, and pro-inflammatory cytokine secretion from macrophages. The kits come in 2 different varieties: standard kits and mannosylated kits (mainly to target central nervous system). To further confirm this finding, we performed a macrophage-depletion treatment experiment using the agent Clodrosome (liposomal clodronate; Encapsula NanoSciences LLC), a liposome suspension encapsulated with clodronate, which selectively leads to macrophage apoptosis . Anti-PD1 antibody led to a significant decrease in the number of OS lung metastases, enhanced tumor apoptosis, decreased tumor cell proliferation, and p-STAT-3/p-Erk1 . Catalog No. Encapsome® is formulated and prepared identically to Clodrosome® except that clodronate is not added to the liposomes. Apr 23rd. Macrophage depletion also remarkedly diminished large platelet aggregate formation in the splenic marginal zone but had less effect on those in red pulp. Standard Macrophage Depletion Kit (Clodrosome® + Encapsome®) DESCRIPTION Clodrosome® is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. Macrophage Depletion Kit (Standard) Each standard macrophage depletion kit contains one vial of Clodronate encapsulated liposomes (Clodrosome) and one vial of plain liposome for control (Encapsome) with the same lipid composition as Clodrosome. used a clodrosome macrophage depletion kit (Encapsula Nano Sciences, Nashville, TN). Depletion of macrophages by clodrosome resulted in reduction of LPS-induced cytokine generation and alleviated LPS-induced thrombocytopenia. Below is a complete list of our Clodrosome Macrophage Depletion Products. for tissues (PD-L1, caspase-3, Ki-67, NK cells, macrophages), and Western blot-ting for OS lung tumors (p-Stat3, p-Erk1/2) was performed. Cytotoxicity of Bisphosphonates such as Clodronate, Pamidronate and Zelodronate. Ccl2, Il1a and Il6 are consequently downregulated in tumors from CCR6-deficient mice. Encapsula Nanosciences. Empty liposomes were injected as the control (Clodrosome Macrophage Depletion Kits, Clodrosome). Conference Chairs For macrophage depletion, mice were given a two-dose vaccination of parental BCG, rBCG1, or rBCG2 (5 × 10 5 CFU per mouse) subcutaneously at weeks 0 and 2, and they received one drop of encapsome® (control) or clodrosome® (Encapsula Nano Sciences, TN, USA) intratracheally weekly for 8 weeks. Read More. For in vivo macrophage depletion, 6- to 8-week-old female C57BL/6 mice received one or three intravenous injections (on days −3, 0, and 3 with respect to DNA vaccination) of 750 μg clodronate disodium formulated in clodrosome (150 μL injection, Encapsula Nanoscience) via retro-orbital injections and control mice each received 150 μL of . Life Technologies, cat through 2 μm polycarbonate membranes to ensure that the larger particles, which may toxic! Maintained under specific-pathogen-free conditions in the if you Encapsome® is formulated and prepared to! 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